Syllabus | Subject: Physical Pharmaceutics-II (Theory) | B. Pharmacy

Course: B. Pharmacy VIth  Semester/ 2nd Year
Name of Subject: Physical Pharmaceutics-II (Theory)
Subject Code:  BP 403 T

Sr. No.


Domain Time
1 Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention. Must 10
2 Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatants, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers Desirable to know 10
3 Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus Nice to know 5
4 Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Physical stability of emulsions, preservation of emulsions, rheological properties of emulsions, phase equilibria and emulsion formulation. Must  know 5
5 Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface. Must to know 10
6 Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action. Must to know 5