Syllabus | Subject: PHARMACOLOGY-I (Theory) | B. Pharmacy

Course: B. Pharmacy 4th semester/ 2nd year

Name of Subject: PHARMACOLOGY-I (Theory)

Subject Code:  BP 404 T.

S. No. Contents of the Topics             Domain Time(Hrs)
1. General Pharmacology
Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.

Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination

Must know 8
2 Pharmacodynamics
Principles and mechanisms of drug action. Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action

Adverse Drug Reactions

Drug interactions (pharmacokinetic and pharmacodynamic)

Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance

Must know

Must know

Nice to know

12
3 Pharmacology of peripheral nervous system

Organization and function of ANS

Neurohumoral transmission,co-transmission and classification of neurotransmitters

Parasympathomimetics Parasympatholytics, Sympathomimetics, sympatholytics.

Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
Local anesthetic agents
Drugs used in myasthenia gravis and glaucoma

Must know

Must know

10
4 Pharmacology of central nervous system
Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.

General anesthetics and pre-anesthetics

Sedatives,
Hypnotics
centrally acting muscle relaxants.
Anti-epileptics

Alcohols and disulfiram

Must know 8
5 Pharmacology of central nervous system

Psychopharmacological agents:
Antipsychotics,
Antidepressants,
Anti-anxiety agents,
Anti-manics and hallucinogens.

Drugs used in Parkinsons disease and Alzheimer’s disease.

CNS stimulants and nootropics.

Opioid analgesics and antagonists

Drug addiction, drug abuse, tolerance and dependence.

Must know

Nice to know

 

Nice to know

 

Must know

7
Admission 2017