Syllabus | Biochemistry Theory | B. Pharmacy

 

Course: B. Pharmacy  IInd Semester /1st Year

   
 

Name of the Subject: Biochemistry Theory

   
 

Subject Code: BP203T

   
Units Topics (Experiments) Domain Hours
1 Carbohydrate metabolism

Glycolysis – Pathway, energetics and significance Citric acid cycle- Pathway, energetics and significance

HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase (G6PD) deficiency

Glycogen metabolism Pathways and glycogen storage diseases (GSD) Gluconeogenesis- Pathway and its significance

Hormonal regulation of blood glucose level and Diabetes mellitus

 

 

Must know

Must know

Must know

Must know

 

 

12
2 Biological oxidation

Electron transport chain (ETC) and its mechanism.

Oxidative phosphorylation & its mechanism and substrate level phosphorylation

Inhibitors ETC and oxidative phosphorylation/Uncouplers

 

 Must know

 Nice to know

 Must know

 

16
3 Lipid metabolism

β-Oxidation of saturated fatty acid (Palmitic acid)

Formation and utilization of ketone bodies; ketoacidosis De novo synthesis of fatty acids (Palmitic acid)

Biological significance of cholesterol and conversion of cholesterol into bile acids, steroid hormone and vitamin D

Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.


Must know

 

Must know


Must know

  Must know

 

12
4 Amino acid metabolism

General reactions of amino acid metabolism: Transamination, deamination & decarboxylation, urea cycle and its disorders

Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenyketonuria, Albinism, alkeptonuria, tyrosinemia)

Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline, adrenaline

Catabolism of heme; hyperbilirubinemia and jaundice


Must know

 

Desirable

 

Must know

Must know

 

12
5 Nucleic acid metabolism and genetic information transfer

Biosynthesis of purine and pyrimidine nucleotides

Catabolism of purine nucleotides and Hyperuricemia and Gout disease Organization of mammalian genome

Structure of DNA and RNA and their functions DNA replication (semi conservative model) Transcription or RNA synthesis

Genetic code, Translation or Protein synthesis and inhibitors

Must know

Must know

Nice to know

 

Must know

 

Desirable

12
6 Biomolecules

Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic acids, amino acids and proteins.

 

 

Must know

 

12
7 Bioenergetics

Concept of free energy, endergonic and exergonic reaction, Relationship between free energy, enthalpy and entropy; Redox potential.

Energy rich compounds; classification; biological significances of ATP and cyclic AMP

 

 

Must know

 

 

Must know

 

12
8 Enzymes

Introduction, properties, nomenclature and IUB classification of enzymes Enzyme kinetics (Michaelis plot, Line Weaver Burke plot)

Enzyme inhibitors with examples

Regulation of enzymes: enzyme induction and repression, allosteric enzymes regulation

Therapeutic and diagnostic applications of enzymes and isoenzymes Coenzymes –Structure and biochemical functions

 

 


Must know

Must know

 

Must know

Must know

 

12
Admission 2017