Curriculum | Physical Pharmaceutics-I(Theory) | B. Pharmacy

Course: B. Pharmacy IIIrd  Semester/ 2nd Year
Name of Subject: Physical Pharmaceutics-I(Theory)
Subject Code:  BP 302 T

Sr. No.

Contents of the Topics

Learning objectives
(should be able to )
Teaching Guidelines Methodology Time
(Hrs)
1 Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, Dissolution & drug release, diffusion principles in biological systems. Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions, azeotropic mixtures, fractional distillation. Partially miscible liquids, Critical solution temperature and applications.

Distribution law, its limitations and applications

To describe various solubility properties and flow properties  of drug molecules in the designing of liquid dosage form Concept of solubility, slovation, dissolution and drug release, Raoult’s law and distribution law. Didactic
PowerPoint Demonstration
Industry Visit

 

 

10
2 States of Matter and properties of matter: State of matter, changes in the state of matter, latent heats, vapor pressure, sublimation critical point, eutectic mixtures, gases, aerosols inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid-crystalline, amorphous & polymorphism.
Physicochemical properties of drug molecules: Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant, determinations and applications
To study various physicochemical properties and flow properties  of drug molecules in the designing of dosage form State of matter, latent heats, vapor pressure, sublimation critical point, eutectic mixtures, gases, aerosols inhalers, relative humidity, liquid complexes, liquid crystals,
Glassy states, solid-crystalline, amorphous & polymorphism.
Refractive index, optical rotation, dielectric constant,
Didactic
PowerPoint Demonstration
10
3 Micromeretics: Particle size and distribution, average particle size, number and weight distribution, particle number, methods for determining particle size by (different methods), counting and separation method, particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties. Demonstrate use of physicochemical properties in evaluation of dosage forms.
Appreciate physicochemical properties of drug molecules in formulation research and Development
Distribution of particles size, Determination of particles size.
Methods for the determination of Surface area and derived properties of powders
Didactic
PowerPoint Demonstration
10
4 Complexation and protein binding: Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants Demonstrate use of physicochemical properties in evaluation of dosage forms.
Appreciate physicochemical properties of drug molecules in formulation research and Development
Concept of complexation, methods of complexation and its applications in detail Didactic
PowerPoint Demonstration
08
5 pH,  buffers  and  Isotonic  solutions:  Sorensen’s  pH  scale,  pH  determination

(electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.

To describe physicochemical properties of drug molecules in formulation research and development Determination of pH, Isotonocity of Solutions and types of Buffer solution available in the market. Didactic
PowerPoint Demonstration
07
Admission 2017