Curriculum | Physical Pharmaceutics-II (Theory) | B. Pharmacy

Course: B. Pharmacy IVth  Semester/ 2nd Year

Name of Subject: Physical Pharmaceutics-II (Theory)

Subject Code:  BP 403 T

Sr. No.

Contents of the Topic

Learning objectives Teaching Guidelines Methodology Time
(Hrs)
1 Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention. At the end of the lecture student should be able to describe and explain concepts on Drug Stability Concept of drug stability, degradation of pharmaceutical products, reaction kinetics, order of reactions and photolytic degradation. Didactic
PowerPoint Demonstration
10
2 Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatants, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers At the end of the lecture student should be able to describe and explain concepts on Rheology Explain about the rheology including types of flow of fluid, determination of viscosity and various viscometers. Didactic
PowerPoint Demonstration
10
3 Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus At the end of the lecture student should be able to describe and explain concepts on deformation of solids Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus Didactic
PowerPoint Demonstration
5
4 Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Physical stability of emulsions, preservation of emulsions, rheological properties of emulsions, phase equilibria and emulsion formulation. At the end of the lecture student should be able to describe and explain concepts on coarse dispersion Concept of biphasic liquid dosage form, formulation of biphasic liquid dosage form, methods of preparation, concept of multiple emulsion and stability studies of biphasic liquid dosage form. Didactic
PowerPoint Demonstration
5
5 Surface and interfacial phenomenon: Liquid interface, surface & interfacial tensions, surface free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid interface. At the end of the lecture student should be able to describe and explain concepts on surface and interfacial phenomenon Concept of surface phenomenon including surface tension, interfacial tension, surface active agents, HLB value and concept of solubilization. Didactic
PowerPoint Demonstration
10
6 Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization & protective action. At the end of the lecture student should be able to describe and explain concepts on colloidal dispersion Explain about the dispersion systems, types of dispersion system, coacervation technique and effect of electrolytes. Didactic
PowerPoint Demonstration
5
Admission 2017