Curriculum | PHARMACOLOGY-I (Theory) | B. Pharmacy

Course: B. Pharmacy 4th semester/ 2nd year

Name of Subject: PHARMACOLOGY-I (Theory)

Subject Code:  BP 404 T.

Unit

Topic (Contents)

Learning Objective ( By the end of lesson should be able to)

Teaching Guidelines

Methodology

Time (Hrs)

1

General Pharmacology
Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.

Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination

  • Describe the scope of pharmacology and routes of administration
  • Factors affecting drug action
  • Explain the pharmacokinetic of drugs
  • Definition and Scope of Pharmacology
  • Sources of Drugs
  • Natural
  • Marine
  • Artificial
  • Plants
  • Different routes of drug Administration
  • Drug, Receptor, Drug receptor combination

 

  • Pharmacokinetics:
  • ADME of Drugs
–Didactic lecture through Power point presentation
–Group discussion
8

2

Pharmacodynamics
Principles and mechanisms of drug action. Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action

Adverse Drug Reactions

Drug interactions (pharmacokinetic and pharmacodynamic)

 

 

Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance

  • In the end of the lecture student should be able to describe the pharmacodynamics of drug

 

 

 

 

  • Describe the adverse drug reactions and drug interactions

 

 

  • Describe the Drug discovery and clinical evaluation of new drugs

 

 

Pharmacodynamics

  • Different Principles and mechanisms of drug action.
  • Classification of Receptors:
  • Ion Channels
  • Ligand Gated ion Channel
  • Kinase linked Receptors
  • Nuclear Receptors
  • Dose Response Relationship

 

  • factors affecting drug action
  • Adverse Drug Reactions
  • Side Effects
  • Idiosyncracy
  • Allergic Reaction
  • Physical Dependence
  • Tolerance etc.

 

  • Drug interactions
  • Pharmacokinetic
  • Pharmacodynamic
  • Drug discovery and clinical evaluation of new drugs
  • Drug discovery phase
  •  preclinical evaluation Phases of clinical trials
  • pharmacovigilance
Instructive
–Power point presentation
–Group discussion

12

3

Pharmacology of peripheral nervous system

Organization and function of ANS

Neurohumoral transmission,co-transmission and classification of neurotransmitters

Parasympathomimetics Parasympatholytics, Sympathomimetics, sympatholytics.

Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
Local anesthetic agents
Drugs used in myasthenia gravis and glaucoma

  • In the end of the lecture student should be able to describe the Organization and function of ANS

 

  • Describe the neurons counduction and transmission of neurotransmitters
  • Describe the Adrenergic and cholinergic receptors along with neuromuscular blocking agents

 

ANS

  • Introduction
  • Structure and functions of ANS
  • Neurohumoral transmission,co-transmission and classification of neurotransmitters

 

  • Parasympathomimetics Parasympatholytics, Sympathomimetics, sympatholytics.
  • Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
  • Local Anaesthetics
  • Classification
  • Mechanism of Action
  • Therapeutic Uses

 

  • Drugs used in myasthenia gravis and glaucoma
  • Classification
  • Mechanism of Action
  • Therapeutic Uses

 

—Instructive
–Power point presentation
—Video lectures

10

4

Pharmacology of central nervous system
Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.

 

 

 

 

General anesthetics and pre-anesthetics

Sedatives, hypnotics and centrally acting muscle relaxants.
Anti-epileptics

Alcohols and disulfiram

  • In the end of the lecture student should be able to describe the Neurohumoral transmission in CNS

 

 

 

  • Describe the general anaesthetics and their categories
  • Explain sedatives, Hypnotics, antiepileptic drugs and their mechanism of action
CNS

  • Introduction
  • Structure and functions of CNS
  • Neurohumoral transmission,co-transmission and classification of neurotransmitters
  • GABA
  •  Glutamate
  •  Glycine
  •  serotonin,
  • Dopamine
  •  Aspartate

 

  • General Anaesthetics
  • Classification
  • Mechanism of Action
  • Therapeutic Uses
  • Sedatives, Hypnotics and Centrally Acting Muscle Relaxants
  • Classification
  • Mechanism of Action
  • Therapeutic Uses

 

  • Antiepileptics
  • Introduction
  • Classification
  • Mechanism of Action
  • Therapeutic Uses
  • Alcohols and disulfiram

 

—Didactic lectures through Power point presentation
–Group discussion

8

5

Pharmacology of central nervous system

Psychopharmacological agents:Antipsychotics, antidepressants, anti-anxiety agents, anti-manics and hallucinogens.

Drugs used in Parkinsons disease and Alzheimer’s disease.

CNS stimulants and nootropics.

Opioid analgesics and antagonists

Drug addiction, drug abuse, tolerance and dependence.

  • In the end of the lecture student should be able to describe the Drugs used in Parkinsons disease and Alzheimer’s disease.

 

  • Describe the CNS stimulants and nootropics.
  • Describe the Opioid analgesics and antagonists
  • Describe the Drug addiction, drug abuse, tolerance and dependence.

 

  • Antipsychotics, antidepressants, anti-anxiety agents, anti- manics and hallucinogens.
  • Introduction
  • Classification
  • Mechanism of Action
  • Therapeutic Uses

 

  • Drugs used in Parkinsons disease and Alzheimer’s disease.
  • Introduction
  • Classification
  • Mechanism of Action
  • Therapeutic Uses
  • CNS stimulants and nootropics.
  • Introduction
  • Classification
  • Mechanism of Action
  • Therapeutic Uses
  • Opioid analgesics and antagonists
  • Introduction
  • Classification
  • Mechanism of Action
  • Therapeutic Uses

 

  • Drug addiction, drug abuse, tolerance and dependence.

 

 

–Instructive
–Power point presentation
–Group discussion

7