Curriculum | Pharmaceutical Organic Chemistry III – Theory | B. Pharmacy

B. Pharmacy 4th semester / 2nd year
Pharmaceutical Organic Chemistry III – Theory
BP401T

Unit Topic Learning objectives Teaching Guidelines Methodology Time (hrs)
Unit-I Stereo isomerism
Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules

DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers

Reactions of chiral molecules

Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute

Explicate Stereo isomerism& asymmetric synthesis.

explain the stereo chemical aspects of organic compounds and stereo chemical reactions

 

explain the method of resolution of racemic mixtures

  • Introduction
  • Plane-polarized  light
  • Polarimeter
  • Specific rotation
  • Optical activity-projection structures of  stereoisomers
  • Properties of enantiomers
  • Racemic modification and resolution
  • Specification of configuration conformational isomers
  • Chiral center-synthesis
  • Reaction of Chiral molecules-bond breaking and relating configuration
  • Optical purity
  • Topicity of ligands

 

Instructive

 

 

Stereomodel
Demonstration

 

Power point presentations

10
UNIT-II Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of configuration of geometrical isomers. Conformational isomerism in Ethane, n-Butane and Cyclohexane.

Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
Stereospecific and stereoselective reactions

`Explain Stereo isomerism& asymmetric synthesis.

explain the stereo chemical aspects of organic compounds and stereo chemical reactions

Clarify isomerism and Stereospecific and stereoselective reactions

  • Introduction
  • Diastereomers
  • Geometric isomers
  • Characterization and configuration of isomers
  • Types of geometric isomerism
  • Conformational isomers
  • Conformational analysis

 

 

Instructive

 

 

Power point presentations

10
UNIT-III Heterocyclic compounds:
Nomenclature and classification
Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene – Relative aromaticity, reactivity and Basicity of pyrrole
Explain the Nomenclature and classification of Heterocyclic compounds.

 

  • Introduction-heterocyclic system
  • Common structural type of heterocycles
  • Structure of pyrrole ,furan and thiophene
  • Source of pyrrole ,furan and thiophene
  • Reactivity and orientation
  • Saturated five membered heterocycles
  • Electophilic substitution and nucleophilic substitution
  • Fused ring heterocycles
Power point presentations

Instructive

 

10

 

UNIT-IV Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrazole, Imidazole, Oxazole and Thiazole.

Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

Explain the methods of preparation, properties and uses of organic compounds.

 

  • Introduction-structure of pyrazole,imidazol,oxazole  and thiazole

– Pyridine, Quinoline, Isoquinoline, Acridine and Indole.

  • Source -pyrazole,imidazol,oxazole  and thiazole

– Pyridine, Quinoline, Isoquinoline, Acridine and Indole.

  • Reactions-pyrazole,imidazol,oxazole  and thiazole

– Pyridine, Quinoline, Isoquinoline, Acridine and Indole.

  • Basicity and acidity – pyrazole,imidazol,oxazole  and thiazole

– Pyridine, Quinoline, Isoquinoline, Acridine and Indole.

  •  Medicinal Uses
instructive
Power point presentations
 

8

 

 

UNIT-V Reactions of synthetic importanc
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.

Oppenauer-oxidation and Dakin reaction.

Beckmanns rearrangement and Schmidt rearrangement. Claisen-Schmidt condensation

Explain the methods of preparation and properties of organic compounds.

Describe the mentioned name reactions and their mechanism

  • Introduction of synthetic compounds
  • Types of reaction
  • Reaction mechanism
  • Electron delocalization
  • Formation of reaction intermediates
  • Transition state
  • Types of reagents
  • Types of organic reactions
  • Kinetic of organic reaction

 

 

Instructive

 

Power point presentations

 

7

 

 

 

Admission 2017