Curriculum | Pharmaceutical Organic Chemistry II – Theory | B. Pharmacy

 

Course

B. Pharmacy  3rd semester / 2nd year
Pharmaceutical Organic Chemistry II – Theory
BP301T

 

Name of Subject

 

Subject Code

 
Unit Topic Learning objectives Teaching Guidelines Methodology Time (hrs)  
Unit -I Benzene and its derivatives
Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule

Reactions of benzene – nitration, sulphonation, halogenation-reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.

Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction

Structure and uses of DDT, Saccharin, BHC and Chloramine

Explain the concept of aromaticity&Hukel rule.

Explain the classification of Benzene and its derivatives.

write the structure, name and the type of isomerism of the organic

 

Discuss the nature and orientation of electrophilic substitution reaction=s of benzene & apply that knowledge in understanding the Structure activity relationship.

Benzene-Aliphatic and aromatic compounds
-Structure of benzene
-molecular formula ,isomer number,kekule structure
-stability of benzene ring and reaction of benzene
-c-c bond lengths in benzene
-resonance structure of benzene
-aromatic character
Polynuclear aromatic hydrocarbons

 

 

Instructive

 

 

 

 

Power point presentations

10  
Unit-II Phenols – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols

Aromatic Amines – Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts

 

explain the concept of acidity & basicity and
Account for reactivity/stability of compounds.
-Introduction
-industrial source
-preparation and physical properties and chemical properties
-rearrangement of derivative
-ring substitution
-kolbe reaction
-Reimer-Tiemann reaction
-formation and reaction  of aryl ethers
-spectroscopic analysis of phenol
Instructive

 

 

Power point presentations

10
 

Unit-III

 

 

 

 

 

Fatty acids – reactions.

Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.

Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.

Explain Saponification and Rancidity of oils, Drying oils.

 

explicate the significance and principle of analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value

 

 

-Nature of oils
-types of oil
-uses of saponification values Acid value,  Ester value, Iodine value, Acetyl value,
-calculation
-significance
-factor affecting the values
 

Demonstartion of isomerism with the help of stereomodels

Power point presentations
Chalk and Board

10
 

Unit-IV

•                Polynuclear hydrocarbons:

a.               Synthesis, reactions

b.               Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives.

write the reaction, name the reaction and orientation of reactions

account for reactivity/stability of compounds,

  • Definition
  • Name of the reaction
  • Synthesis process
  • Type of reaction
  • Application

 

 

Instructive

 

Power point presentations

8
Unit-V  

Cyclo alkanes
Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

Account for reactivity/stability of compounds, Introduction
-industrial source
-laboratory preparation
-reaction
-cyclopropane and cyclobutane
-factors affecting stability of cycloalkanes
-equatorial and axial bonds in cyclohexane
 

Instructive

Power point presentations

 

 

7