Curriculum | Pharmaceutical Organic Chemistry I – Theory | B. Pharmacy

Course: B. Pharmacy 2nd Semester/ 1st  Year
Name of Subject: Pharmaceutical Organic Chemistry I – Theory
Subject Code:  BP202T
S No. Contents of the Topics Learning objectives Teaching guidelines Methodology Time

(Hrs)

1 Classification, nomenclature and isomerism

 

Classification of Organic Compounds

 

Common and IUPAC systems of nomenclature of organic compounds  (up to 10 Carbons open chain and carbocyclic compounds)

 

 

Structural isomerisms in organic compounds

Explain classification of organic compounds.

 

write the structure, name of compounds and know about the type of isomerism of the organic compounds

 

 

 

 

explain the Structure activity relationship

Concept of word root

primary and secondary prefixes and suffixes

Concept of isomerism

Types of isomerism

Concept of chirality and symmetry

Enantiomerism,diastereomerism and meso compound

Recemization and resolution

Walden inversion

Configuration in terms of D & L

Sequence rules and R&S rotation

 

Instructive

 

Class discussion

 

 

 

 

Demonstration of isomerism with the help of stereo models

 

07
2 Alkanes, Alkenes, Conjugated dienes

 

SP3 hybridization in alkanes,

Halogenation of alkanes,

uses of paraffins.

Stabilities of alkenes,

SP2 hybridization in alkenes

 

E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and evidences.

E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation.

 

Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement

 

Enumerate  basic functional groups.

Explain factors affecting the reactivity & stability order of alkyl of alkyl halides

To differentiate between E1 & E2 reactions.

Application of Markownikoff’s rule & Saytzeffs orientation in organic reactions.

Elucidate stability of conjugated dienes & their application in reaction mechanism.

Concept of word root

primary and secondary prefixes and suffixes

Concept of isomerism

Types of isomerism

Concept of chirality and symmetry

Enantiomerism,diastereomerism and meso compound

Recemization and resolution

Walden inversion

Configuration in terms of D & L

Sequence rules and R&S rotation

 

Instructive

 

Class discussion

 

 

 

 

Demonstration of isomerism with the help of stereo models

 

10
3 Alkyl halides*

SN1 and SN2 reactions – kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.

 

SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions

 

Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform.

 

·        Alcohols*- Qualitative tests, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol

 

 

 

Explain Stereochemistry and rearrangement of carbocations.

 

To differentiate between SN1 & SN2 reactions

 

write the reaction, name the reaction and orientation of reactions

 

Account for reactivity/stability of compounds

 

Pharmaceutical application of the organic compounds

 

 

 

Structure ,nomenclature and isomerism of alkanes ,alkenes and conjugated dienes

Preparation of alkanes & alkenes

Physical properties and chemical properties of alkanes & alkenes

Mechanism of halogenations ,polymerization ,substitution reaction

Mechanism of E1 &E2 reaction

Mechanism of Markownikov’s addition  and  anti- Markownikov’s ozonolysis  and its application

Reactivity and selectivity of  alkanes & alkenes

Structure and stability of conjugated dienes

Relative stability of Dienes

Chemical reaction of dienes

Electrophilic addition reactions

Diel alder reaction

 

 

 

 

 

 

Instructive

 

Student reports

 

 

 

Power point presentations

 

 

Assignment to outline portions of the textbook

10
4 Carbonyl compounds (Aldehydes and ketones)

Nucleophilic addition, Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests,

Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.

 

In the end of the lecture the student should be able to write the reaction, name the reaction and orientation of reactions

 

Nomenclature of alkyl halides-common system & IUPAC system

Structure of alkyl halides

Physical properties and chemical properties of alkyl halides

Nucleophilic substitution reaction (SN- Reaction)

Types-SN2 & SN1

Comparison of SN 2  and SN 1 Reactions

Vinyl halide

Substitution Versus Elimination

 

Nomenclature of alcohols -common system & IUPAC system

Structure of alcohols Physical properties and chemical properties of alcohols and reactivity and stability

Name reaction

 

 

Demonstartion of isomerism with the help of stereomodels

 

 

Class projects

 

Power point presentations

 

 

 

 

Recitation oral questions

 

 

10
5 ·        Carboxylic acids*

Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for carboxylic acids ,amide and ester Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid

Aliphatic amines- Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine

 

 

Explain the concept of acidity.

 

 

Identify/confirm the identification of organic compound.

 

 

write the structure, name and Pharmaceutical application of the organic

 

 

Explain the concept of basicity.

 

 

Identify/confirm the identification of organic compound.

 

Nomenclature of Carbonyl compounds -common system & IUPAC system

Structure of aldehyde and ketone  Physical properties and chemical properties of aldehyde and ketone   and reactivity and stability

 

Nomenclature of alkyl halides-common system & IUPAC system

Structure of Carboxylic acids

Physical properties and chemical properties of Carboxylic acids

Application of various acids in pharmaceutical industry

 

Nomenclature of aliphatic amines -common system & IUPAC system

Structure of aliphatic amines

Physical properties and chemical properties of aliphatic aminesName reaction

Presentations by student panels from the class

 

 

 

 

 

Power point presentations

 

8
Admission 2017