Curriculum | Pharmaceutical Medicinal Chemistry III – Theory| B. Pharmacy

Course

B. Pharmacy Semester-6th / 3rd Year

 

Name of Subject

Pharmaceutical Medicinal Chemistry III – Theory

 

Subject Code

BP601T

 
Unit Sub Units

Topic

Learning objectives

Teaching guidelines

Methodology Time (hrs)
Unit-I 1.1 Study of the development of the following classes of drugs, Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted by
Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.
β-Lactam antibiotics: Penicillin, Cepholosporins, β- Lactamase inhibitors, Monobactams
Aminoglycosides: Streptomycin, Neomycin, Kanamycin
Tetracyclines:Tetracycline,Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline
Explain  Classification, mechanism of action, uses of drugs
Describe the drug design and different techniques of drug design.
Explain the chemistry of drugs with respect to their biological activity.
Elucidate the metabolism, adverse effects and therapeutic value of drugs.
Explain the importance of SAR of drugs.

 

 

  • Introduction
  • Types of antibiotics (broad spectrum  and narrow spectrum  )
  • Classification of drugs
  • Stereochemistry
  • Mode of action
  • Drug Synthesis
  • Mechanism
  • Drug interaction and contraindication
  • Dose and uses of each drugs
  • Structure activity relationship of selective class of drugs
Instructive
Flowcharts
Power point presentations
Group Discussion
Class test
10
UNIT-II 2.1  

Antibiotics

Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes
Macrolide: Erythromycin Clarithromycin, Azithromycin.
Miscellaneous: Chloramphenicol*, Clindamycin.

Prodrugs: Basic concepts and application of prodrugs design.

Antimalarials: Etiology of malaria.

Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine.

Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil.

Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone

 

Describe Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation of drugs.

Explain the chemistry of drugs with respect to their biological activity.

Be acquainted with the metabolism, adverse effects and therapeutic value of drugs.

Describe the importance of SAR of drugs.

 

  • Introduction
  • Classification of drugs
  • Stereochemistry
  • Mode of action
  • Drug Synthesis
  • Mechanism
  • Drug interaction and contraindication
  • Dose and uses of each drugs
  • Structure activity relationship of selective class of drugs
Instructive

 

Flowcharts

Power point presentations
Group Discussion
Class test

 

10
UNIT-III  

3.1

Anti-tubercular Agents

Synthetic anti tubercular agents: Isoniozid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid.*

Anti tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine Streptomycine, Capreomycin sulphate.
Urinary tract anti-infective agents
Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin
Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine.
Antiviral agents:
Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir.

Describe Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation of drugs.

Explain the chemistry of drugs with respect to their biological activity.

Be acquainted with the metabolism, adverse effects and therapeutic value of drugs.

Explain the importance of SAR of drugs.

 

 

  • Introduction
  • Classification of drugs
  • Stereochemistry
  • Mode of action
  • Drug Synthesis
  • Mechanism
  • Drug interaction and contraindication
  • Dose and uses of each drugs
  • Structure activity relationship of selective class of drugs
 

Demonstration of isomerism with the help of stereo models
Group Discussion
Class test
Flowcharts

Power point presentations

 

 

 

Flowcharts

10
UNIT-IV 4.1 Antifungal agents:
Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin.
Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconozole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate*.
      Sulphonamides and Sulfones
Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxaole*, Sulphadiazine, Mefenide acetate, Sulfasalazine.
Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole.
Sulfones: Dapsone*.
Describe Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation of drugs.

Elucidate the chemistry of drugs with respect to their biological activity.

Be acquainted with the metabolism, adverse effects and therapeutic value of drugs.

Explain the importance of SAR of drugs.

  • Introduction
  • Classification of drugs
  • Mode of action
  • Drug Synthesis
  • Mechanism
  • Drug interaction and contraindication
  • Dose and uses of each drugs
  • Structure activity relationship of selective class of drugs
Flowcharts
Through Models & Chart, Tutorial, Instructive
Power point presentations
8
UNIT-V 5.1 Introduction to Drug Design
Various approaches used in drug design.
Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammet’s electronic parameter, Tafts steric parameter and Hansch analysis.
Pharmacophore modeling and docking techniques.
Combinatorial Chemistry: Concept and applications of combinatorial chemistry: solid phase and solution phase synthesis.
 

Explain the chemistry of drugs with respect to their biological activity.

Be acquainted with the metabolism, adverse effects and therapeutic value of drugs.

Explain the importance of SAR of drugs.

  • Introduction
  • Recent advances in the area of drug discovery
  • Current trends in drug discovery
  • Need for virtual screening
  • Novel approach –scaffold hopping
  • DOCK,Flex X,OXP,ICM,LEADS,UTO dOCK
  • Applications

 

 

Power point presentations
Flowcharts
Through Models & Chart, Tutorial, Instructive

 

 

07
Admission 2017