Curriculum | Pharmaceutical Medicinal Chemistry III – Practical | B. Pharmacy

Course

B. Pharmacy Semester 6th / 3rd Year

 

Name of Subject

Pharmaceutical Medicinal Chemistry III – Practical

 

Subject Code

BP607P

 

Unit

Topic

Learning objectives Teaching guidelines Methodology

Time (hrs)

Unit-I

Preparation of drugs and intermediates

  1. Sulphanilamide
  2. 7-Hydroxy, 4-methyl coumarin
  3. Chlorobutanol
  4. Triphenyl imidazole
  5. Tolbutamide
  6. Hexamine
Explain the correct use of various equipments & Safety measures in Pharmaceutical Chemistry laboratory.

Explain how to synthesize different organic compounds along with reaction & Mechanism.

 

 

.

 

Proper procedure

Result

Label

Melting point

Determination

Percent yield

 

Instructive

 

Practical Demonstration of working of various instruments in the laboratory.

4 hrs/week

  Assay of drugs

  1. Isonicotinic acid hydrazide
  2. Chloroquine
  3. Metronidazole
  4. Dapsone
  5. Chlorpheniramine maleate
  6. Benzyl penicillin
Explain how to assay various  drug compounds along with reaction, Mechanism  and their uses Proper procedure

Percent purity determination

Result

Label

Melting point

Determination

Percent yield

Instructive
Practical Demonstration of working of various instruments in the laboratory.

4 hrs/week

 
  1. Preparation of medicinally important compounds or intermediates by Microwave irradiation technique
Describe the significance of microwave & how to synthesize different organic compounds along with reaction & Mechanism. Heating effect
Selective heating
Microwave effect
catalysis
small groups such as task oriented, discussion,

4 hrs/week

  Drawing structures and reactions using chem. draw® How to use chem draw® Calculation and software handling Applying simple statistical techniques to class data

4 hrs/week

  Determination of physicochemical properties such as logP, clogP, MR, Molecular weight, Hydrogen bond donors and acceptors for class of drugs course content using drug design software Drug likeliness screening (Lipinskies RO5) How to use various software for the determination of physical and chemical properties
Lipinskies ROS –This   Rule Describes Molecular Properties Important For A Drug’s Pharmacokinetics In The Human Body
Software handling Applying simple statistical techniques to class data

4 hrs/week