Curriculum | Pharmaceutical Engineering ( Theory) | B. Pharmacy

Course : B Pharmacy 3rd semester / 2nd year

Name of Subject: Pharmaceutical Engineering ( Theory)

Subject Code: BP304T

Sr. No.

Contents of the topics

Learning objectives Teaching Guidelines Methodology Time
(Hrs)
1. Flow of fluids: Types of manometers, Reynolds number and its significance,  Bernoulli’s  theorem  and  its  applications,  Energy  losses,  Orifice  meter,  Venturimeter, Pitot tube and Rotometer. To describe and describe various unit operations used in Pharmaceutical industries and material handling techniques with respect to flow of fluids Concept of flow of fluid, its application in industries and how to regulate and control the flow of fluid. Didactic
PowerPoint Demonstration
2
2 Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of Hammer mill, ball mill, fluid energy mill, Edge runner mill & end runner mill. To perform various processes involved in pharmaceutical manufacturing process related to size reduction.

 

Explain size reduction process, factors affecting the process and equipments used for the reduction of size of the particles. Didactic
PowerPoint Demonstration
3
3 Size Separation: Objectives, applications & mechanism of size separation, official standards of powders, sieves, size separation Principles, construction, working, uses, merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank. To perform various processes involved in pharmaceutical manufacturing process related to size separation. Concept of size separation, objective, its applications in the pharmaceuticals and detail description of different equipments used for the size separation process. Didactic
PowerPoint Demonstration
2
4 Mixing: Objectives, applications & factors affecting mixing, Difference between solid and liquid mixing, mechanism of solid mixing, liquids mixing and semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits of Double cone blender, twin shell blender, ribbon blender, Sigma blade mixer, planetary mixers, Propellers, Turbines, Paddles & Silverson Emulsifier To perform various processes involved in pharmaceutical manufacturing process related to mixing. Process of mixing of solid, liquids and semisolid.
Explain in detail about the equipments used for the process of mixing of pharmaceutical products.
Didactic
PowerPoint Demonstration
3
5 Crystallization: Objectives, applications, & theory of crystallization. Solubility curves, principles, construction, working, uses, merits and demerits of Agitated batch crystallizer, Swenson Walker Crystallizer, Krystal crystallizer, Vacuum crystallizer. Caking of crystals, factors affecting caking & prevention of caking. To perform various processes involved in pharmaceutical manufacturing process related to crystallization
.
Concept and objective of crystallization.
Solubility curves and different methods of crystallization.
Didactic
PowerPoint Demonstration
3
6 Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law, Heat transfer by conduction, convection & radiation. Heat interchangers & heat exchangers To perform various processes involved in pharmaceutical manufacturing process related to Heat transfer Explain about the different methods of heat transfer and application of heat transfer in pharmaceutical industries. Didactic
PowerPoint Demonstration
3
7 Evaporation: Objectives, applications and factors influencing evaporation, differences between evaporation and other heat process. principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect evaporator& Economy of multiple effect evaporator. To perform various processes involved in pharmaceutical manufacturing process related to Evaporation Process of evaporation, application of evaporation processes and detail description about the different equipments used for the evaporation process in laboratories and at industrial scale. Didactic
PowerPoint Demonstration
4
8 Drying: Objectives, applications & mechanism of drying process, measurements & applications of Equilibrium Moisture content, rate of drying curve. principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer spray dryer, fluidized bed dryer, vacuum dryer, freeze dryer. To describe and differentiate various heating and drying processes. Concept of drying, mechanism of drying process and equipments used in the drying process for different pharmaceutical materials. Didactic
PowerPoint Demonstration
5
9 Distillation: Objectives, applications & types of distillation. principles, construction, working, uses, merits and demerits of (lab scale and industrial scale) Simple distillation, preparation of purified water and water for injection BP by distillation, flash distillation, fractional distillation, distillation under reduced pressure, steam distillation & molecular distillation To describe and describe various distillation processes used in Pharmaceutical industries w r t Distillation. Process of distillation, types and application of distillation in laboratories as well as at large scale production. Didactic
PowerPoint Demonstration
5
10 Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf, rotary drum filter, Meta filter & Cartridge filter, membrane filters and Seidtz filter.      To describe and describe various distillation processes and their applications used in Pharmaceutical industries w r t Filtration Concept of filtration process. Construction, working, principle and used of different instruments used for the filtration process. Didactic
PowerPoint Demonstration
4
11 Centrifugation: Objectives, principle & applications of Centrifugation, principles, construction, working, uses, merits and demerits of Perforated basket centrifuge, Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge. To describe and describe various centrifugation processes and their applications with respect to size separation technique used in Pharmaceutical industries w r t centrifugation Process of centrifugation its applications in industries and detail description related to the equipments used for the centrifugation. Didactic
PowerPoint Demonstration
4
12 Plant location: industrial hazards and plant safety: Plant Layout, utilities and services, Mechanical hazards, Chemical hazards, Fire hazards, explosive hazards and their safety. To describe and explain utility of plant layout and importance of knowledge of hazards. At plant location Plant layout and different safety measures related to chemicals and equipments in the industries. Didactic
PowerPoint Demonstration
2
13 Materials of pharmaceutical plant construction: Corrosion and its prevention: Factors affecting during materials selected for Pharmaceutical plant construction, Theories of corrosion, types of corrosion and there prevention. Ferrous and nonferrous metals, inorganic and organic non metals. To describe and explain utility of plant layout and importance of knowledge of hazards. Concept of corrosion for the construction materials in plant and its long life aspects and factors influencing the material selection Didactic
PowerPoint Demonstration
3
14 Material handling systems: Objectives & applications of Material handling systems, different types of conveyors such as belt, screw and pneumatic conveyors. To describe and describe various unit operations used in Pharmaceutical industries and material handling systems Explain about the different conveyors used for the handling of materials like solids, liquids and semisolids in the industries. Didactic
PowerPoint Demonstration

 

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