Curriculum | Formulative Pharmacy- (Theory) | B. Pharmacy

Course: B. Pharmacy Vth  Semester/ 3rd  Year
Name of Subject: Formulative Pharmacy-  (Theory)
Subject Code:  BP 502 T

S. No. Contents of the Topics Learning Objectives Teaching Guidelines Methodology Time(Hrs)
Preformulation Studies: Introduction to Preformulation, goals and objectives, study of physicochemical characteristics of drug substances.

  • Physical properties: Physical form (crystal & amorphous), particle size, shape, flowproperties, solubility profile (pKa, pH, partition coefficient), polymorphism.
  • Chemical Properties: Hydrolysis, oxidation, reduction, racemization, polymerizationBCS classification of drugs

Application of Preformulation considerations in the development of solid, liquid oral and parenteral dosage forms and its impact on stability of dosage forms.

At the end of the lecture student should be able to describe  and explain various aspects of preformulation studies
  • Physical form (crystal & amorphous), particle size, shape, flowproperties, solubility profile (pKa, pH, partition coefficient), polymorphism
  • Hydrolysis, oxidation, reduction, racemization, polymerizationBCS classification of drugs
  • Application of Preformulation considerations in the development of solid, liquid oral and parenteral dosage forms and its impact on stability of dosage forms

 

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
Class discussions conducted by a student or student committee
03
Tablets:
Introduction, ideal characteristics of tablets, classification of tablets. Excipients, Formulation of tablets, granulation methods, compression and processing problems. Equipments and tablet tooling.

  • Tablet coating: Types of coating, coating materials, formulation of coating composition, methods of coating, equipment employed and defects in coating.
  • Quality control tests: In process and finished product tests
At the end of the lecture student should be able to  describe and explain various aspects of Tablets
  • Introduction
  • classification of tablets
  • Formulation of tablets
  • granulation methods, compression and processing problems
  • Tablet coating
  • Quality control tests
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
Class discussions conducted by a student or student committee
07
Liquid orals: Formulation and manufacturing consideration of solutions, suspensions and emulsions; Filling and packaging; evaluation of liquid orals official in pharmacopoeia At the end of the lecture student should be able to describe and explain various aspects of Liquid orals
  • Formulation and manufacturing consideration of solutions, suspensions and emulsions
  • Filling and packaging; evaluation of liquid orals official in pharmacopoeia

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
Class discussions conducted by a student or student committee
03
Capsules:

  • Hard gelatin capsules: Introduction, Extraction of gelatin and production of hardgelatin capsule shells. Size of capsules, Filling, finishing and special techniques of formulation of hard gelatin capsules. In process and final product quality control tests for capsules.
  • Soft gelatin capsules: Nature of shell and capsule content, size ofcapsules, importance of base adsorption and minimum/gram factors, production, in process and final product quality control tests. Packing, storage and stability testing of soft gelatin capsules
At the end of the lecture student should be able to  describe and explain various aspects of Capsules
  • Introduction
  • Extraction of gelatin and production of hardgelatin capsule shells
  • Size of capsules, Filling, finishing and special techniques of formulation of hard gelatin capsules
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practical
04
Pellets: Introduction, formulation requirements, pelletization process, equipments for manufacture of pellets At the end of the lecture student should be able to  describe and explain various aspects of pellets
  • Introduction
  • Formulation
  • Requirements
  • Pelletization process
  • Equipments for manufacture of pellets
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practical
04
Parenteral Products:

  • Definition, types, advantages and limitations. Preformulation factors and essential requirements, vehicles, additives, importance of isotonicity
  • Production procedure, production facilities and controls.
  • Formulation of injections, sterile powders, emulsions, suspensions, large volume parenteral and lyophilized products, Sterilization.
  • Containers and closures selection, filling and sealing of ampoules, vials and infusion fluids. Quality control tests.
At the end of the lecture student should be able to  describe and explain various aspects of parentral products
  • Definition
  • Types
  • Advantages and limitations
  • Preformulation factors and essential
  • Requirements
  • Vehicles
  • Additives
  • Importance of isotonicity
  • Formulation of injections, sterile powders, emulsions, suspensions
  • Containers and closures selection, filling and sealing of ampoules
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
05
Ophthalmic Preparations: Introduction, formulation considerations; formulation of eye drops, eye ointments and eye lotions; methods of preparation; labeling, containers; evaluation of ophthalmic preparations At the end of the lecture student should be able to  describe and explain various aspects of ophthalmic preparations
  • Introduction
  • formulation considerations
  • formulation of eye drops, eye ointments and eye lotions
  • methods of preparation labeling
  • containers
  • evaluation of ophthalmic preparations

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
05
Cosmetics: Formulation and preparation of the following cosmetic preparations: lipsticks, shampoos, cold cream and vanishing cream, tooth pastes, hair dyes and sunscreens. At the end of the lecture student should be able to  describe  and explain various aspects of cosmetics
  • Formulation and preparation  lipsticks, shampoos, cold cream
  • Vanishing cream, tooth pastes, hair dyes and sunscreens.
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
05
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol systems; formulation and manufacture of aerosols; Evaluation of aerosols; Quality control and stability studies. At the end of the lecture student should be able to  describe  and explain various aspects of aerosols
  • Definition, propellants
  • containers valves
  • Types of aerosol systems formulation and manufacture of aerosols Evaluation of aerosols Quality control and stability studies.
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
05
Packaging Materials Science: Materials used for packaging of pharmaceutical products, factors influencing choice of containers, legal and official requirements for containers, stability aspects of packaging materials, quality control tests. At the end of the lecture student should be able to  describe and explain various aspects of packaging material
  • Materials used for packaging of pharmaceutical product
  • Factors influencing choice of containers
  • Legal and official requirements for containers
  • Stability aspects of packaging materials, quality control tests.
Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals
05
Admission 2017