Curriculum | Experimental Pharmacology | B. Pharmacy

Course: B. Pharmacy 8th Sem/4th year
Name of Subject: Experimental Pharmacology
Subject Code:  BP 810ET
S No. Contents of the Topics Learning objectives

(In the end of unit the student must be able to)

Teaching guidelines Methodology Time

(Hrs)

1 Laboratory Animals:

Study of CPCSEA and OECD guidelines for maintenance, breeding and conduct of experiments on laboratory animals, Common lab animals: Description and applications of different species and strains of animals. Popular transgenic and mutant animals.

Techniques for collection of blood and common routes of drug administration in laboratory animals, Techniques of blood collection and euthanasia

enumerate CPCSEA and OECD guidelines for the conduct of experiments on laboratory animals Explanation of CPCSEA and OECD guidelines for conduction of laboratory animals Power point presentation

 

8Hrs
2 Preclinical screening models

(a)     Introduction: Dose selection, calculation and conversions, preparation of drug solution/suspensions, grouping of animals and importance of sham negative and positive control groups. Rationale for selection of animal species and sex for the study.

(b)     Study of screening animal models for

Diuretics, nootropics, anti-Parkinson’s, antiasthmatics

Preclinical screening models: for CNS activity- analgesic, antipyretic,anti-inflammatory, general anaesthetics, sedative and hypnotics, antipsychotic, antidepressant, antiepileptic, antiparkinsonism, alzheimer’s disease

describe various preclinical screening models especially for diuretics, nootropics, anti-Parkinson’s, antiasthmatics

and describe preclinical screening models for CNS activity

Demonstration of preclinical screening models for various drugs

 

Power point presentation

Group discussion, Software

 

10
3 Preclinical screening models: for ANS activity, sympathomimetics, sympatholytics, parasympathomimetics, parasympatholytics, skeletal muscle relaxants, drugs acting on eye, local anesthetics In the end of the lecture student should be able to describe preclinical screening models for ANS activity Power point presentation

Group discussion, Software, Lab Practicals

5
4 Preclinical screening models: for CVS activity- antihypertensives, diuretics, antiarrhythmatic, antidyslepidemic, anti aggregatory, coagulants, and anticoagulants

Preclinical screening models for other important drugs like antiulcer, antidiabetic, anticancer and antiasthmatics.

enumerate preclinical screening models for CVS activity, antiulcer,antidiabetics, anticancer and antiasthmatics Demonstration of preclinical screening models for CVS activity, antiulcer,antidiabetics, anticancer and antiasthmatics  

PowerPoint Demonstration

Lab Practicals,

 

4
5 Research methodology and Bio-statistics

Selection of research topic, review of literature, research hypothesis and study design

Pre-clinical data analysis and interpretation using Student‘t’ test and One-way ANOVA. Graphical representation of data

analyse and interpret experimental data Discussion of research methodology and bio-statistics Through software, PowerPoint demonstration

 

5
Admission 2017