Curriculum | BIOPHARMACEUTICS AND PHARMACOKINETICS (Theory) | B. Pharmacy

Course: B. Pharmacy 6th Semester/ 3rd Year
Name of Subject:  BIOPHARMACEUTICS AND PHARMACOKINETICS (Theory)
Subject Code:   BP604 T

S. No. Contents of the Topics

Learning objectives

Teaching guidelines

Methodology

Time
(Hrs)
Introduction to Biopharmaceutics

Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes, Distribution of drugs Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs

At the end of the lecture student should be able to describe the basic concepts in biopharmaceutics and pharmacokinetics.
  • Mechanisms of drug absorption through GIT, factors influencing drug absorption though GIT, absorption of drug from Non per oral extra-vascular routes
  • Distribution of drugs Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding,

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals,  quiz, assignments, open book tests, field work, group discussions , seminar ,presentations, student teacher interactions,

10

Drug Elimination renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs

Bioavailability and Bioequivalence: Objectives of bioavailability studies, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro, in-vivo correlations, bioequivalence studies, methods to enhance the bioavailability.

At the end of the lecture student should be able to Use plasma data and derive the pharmacokinetic parameters to describe the process of drug absorption, distribution, metabolism and elimination.
  • Drug Elimination renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs

 

  • Bioavailability and Bioequivalence: Objectives of bioavailability studies, absolute and relative bioavailability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro, in-vivo correlations, bioequivalence studies, methods to enhance the bioavailability.

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals,  quiz, assignments, open book tests, field work, group discussions , seminar ,presentations, student teacher interactions,

10

Hours Pharmacokinetics: Introduction to Pharmacokinetics models, Compartment models, Non compartment models, physiological models, One compartment open model. a. Intravenous Injection (Bolus) b. Intravenous infusion, extra vascular administrations, calculations of Ka, KE. From plasma and urinary excretion data At the end of the lecture student should be able to describe Design and evaluate dosage regimens of the drugs using pharmacokinetic and biopharmaceutic parameters
  • Pharmacokinetics models, Compartment models, Non compartment models, physiological models,
  • One compartment open model. a. Intravenous Injection (Bolus) b. Intravenous infusion, extra vascular administrations, calculations of Ka, KE. From plasma and urinary excretion data

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals,  quiz, assignments, open book tests, field work, group discussions , seminar ,presentations, student teacher interactions,

10

Multicompartment models: Two compartment open model. IV bolus

Multiple – Dosage Regimens:

a). Repititive Intravenous injections – One Compartment Open Model

b). Repititive Extravascular dosing – One Compartment Open model

At the end of the lecture student should be able to  describe theory of compartmental models
  • Repititive Intravenous injections – One Compartment Open Model

 

  • Repititive Extravascular dosing – One Compartment Open model

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practicals,  quiz, assignments, open book tests, field work, group discussions , seminar ,presentations, student teacher interactions,

08

Nonlinear Pharmacokinetics: a. Introduction, b. Factors causing Non-linearity.

c. Michaelis-menton method of estimating parameters, Biotransformation of drugs

At the end of the lecture student should be able to  describe Non linear pharmacokinetics
  • Introduction
  • Factors causing Non-linearity.
  • Michaelis-menton method of estimating parameters, Biotransformation of drugs

Didactic
PowerPoint Demonstration
Industry Visit
Lab Practical,  quiz, assignments, open book tests, field work, group discussions , seminar ,presentations, student teacher interactions,

07